P02-019 - Detection of risk factors for AA-amyloidosis

P02-019 - Detection of risk factors for AA-amyloidosis

Introduction Systemic reactive (AA) amyloidosis represents the most important complication within TNF receptor associated periodic syndrome (TRAPS), familial Mediterranean fever (FMF) and other autoinflammatory syndromes, progressively leading to endstage renal failure. The homozygous condition of the serum amyloid A (SAA) variant SAA1.1 is significantly associated with the occurrence of AA amy...

PW03-029 – Risk factors for AA-type amyloidosis in Germany

Methods Seventy-three patients with FMF and 39 patients with active systemic inflammation due to autoimmune or idiopathic inflammation were evaluated in our reference center for amyloidosis. Mutations in MEFV and the SAA-1 exon 3 variants were analyzed for their contribution to AA risk. Amyloidosis was detected in all cases by congo red staining of kidney or bowel biopsy specimens and AA was cl...

Tocilizumab for the Treatment of AA Amyloidosis

Anti-Cytokine Therapy for AA Amyloidosis

BIOLOGICAL SCIENCES: Medical Sciences Pathogenetic mechanisms of AA amyloidosis Short title: Pathogenesis of AA amyloidosis

a Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, UK; b Centre for Biomedical Science, Division of Medicine, University College London, London NW3 2PF, UK; Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy; d Centre for Neuroendocrinology, Division of Medicine, University Colle...